| 2. Jornada | 06.03.2021 | Paphos FC | - | APOEL Nikosia | 1:1 | ||||
| 3. Jornada | 15.03.2021 | APOEL Nikosia | - | Karmiotissa Polemidion | 2:0 | ||||
| 4. Jornada | 19.03.2021 | APOEL Nikosia | - | Doxa Katokopias | 1:0 | ||||
| 5. Jornada | 04.04.2021 | Nea Salamina | - | APOEL Nikosia | 1:2 | ||||
| 6. Jornada | 10.04.2021 | APOEL Nikosia | - | Enosis Neon Paralimni | 1:0 | ||||
| 7. Jornada | 17.04.2021 | Ermis Aradippou | - | APOEL Nikosia | 2:0 |  |
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| 9. Jornada | 05.05.2021 | APOEL Nikosia | - | Paphos FC | 0:1 | ||||
| 12. Jornada | 20.05.2021 | APOEL Nikosia | - | Nea Salamina | 0:0 | ||||
| 13. Jornada | 24.05.2021 | Enosis Neon Paralimni | - | APOEL Nikosia | 0:1 | ||||
| 14. Jornada | 28.05.2021 | APOEL Nikosia | - | Ermis Aradippou | 2:0 |
Chipre