| 1. Jornada | 07.11.2021 | AEP Iraklis FC | - | Niki Volou FC | 0:0 | ||||
| 2. Jornada | 13.11.2021 | Niki Volou FC | - | Veria FC | 2:2 | ||||
| 3. Jornada | 21.11.2021 | Apollon Pontou | - | Niki Volou FC | 0:0 | ||||
| 6. Jornada | 05.12.2021 | Niki Volou FC | - | Xanthi FC | 0:1 | ||||
| 7. Jornada | 11.12.2021 | Thesprotos | - | Niki Volou FC | 2:0 | ||||
| 13. Jornada | 13.01.2022 | Niki Volou FC | - | AO Trikala | 3:0 |  |
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| 14. Jornada | 16.01.2022 | AE Lárissa | - | Niki Volou FC | 1:0 | ||||
| 9. Jornada | 19.01.2022 | Almopos Arideas | - | Niki Volou FC | 0:0 | ||||
| 11. Jornada | 27.01.2022 | Niki Volou FC | - | Olympiacos Volou | 1:0 | ||||
| 16. Jornada | 30.01.2022 | Olympiakos Piraeus II | - | Niki Volou FC | 2:0 | ||||
| 12. Jornada | 02.02.2022 | PAOK Saloniki II | - | Niki Volou FC | 2:2 | |
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| 17. Jornada | 05.02.2022 | Niki Volou FC | - | Panserraikos | 1:0 |  |
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| 18. Jornada | 12.02.2022 | Niki Volou FC | - | AEP Iraklis FC | 1:1 | ||||
| 20. Jornada | 20.02.2022 | Niki Volou FC | - | Apollon Pontou | 1:0 | ||||
| 28. Jornada | 02.04.2022 | Olympiacos Volou | - | Niki Volou FC | 1:2 | ||||
| 30. Jornada | 10.04.2022 | AO Trikala | - | Niki Volou FC | 0:3 |
Grecia