| 2. Jornada | 26.01.2019 | Club Nacional | - | Guaraní | 0:2 |  |
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| 3. Jornada | 02.02.2019 | Guaraní | - | Libertad | 3:1 | ||||
| 4. Jornada | 07.02.2019 | San Lorenzo | - | Guaraní | 1:3 | |
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| 5. Jornada | 12.02.2019 | Guaraní | - | Deportivo Capiatá | 1:2 | ||||
| 6. Jornada | 15.02.2019 | Sportivo Luqueño | - | Guaraní | 0:2 | ||||
| 7. Jornada | 24.02.2019 | Guaraní | - | General Díaz | 1:1 | |
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| 12. Jornada | 23.03.2019 | Cerro Porteño | - | Guaraní | 5:2 | |
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| 13. Jornada | 31.03.2019 | Guaraní | - | Club Nacional | 2:2 | ||||
| 15. Jornada | 09.04.2019 | Guaraní | - | San Lorenzo | 4:1 | |
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| 16. Jornada | 13.04.2019 | Deportivo Capiatá | - | Guaraní | 0:1 | ||||
| 14. Jornada | 18.04.2019 | Libertad | - | Guaraní | 1:1 | ||||
| 18. Jornada | 27.04.2019 | General Díaz | - | Guaraní | 1:1 | ||||
| 19. Jornada | 30.04.2019 | Guaraní | - | Deportivo Santaní | 0:0 | ||||
| 20. Jornada | 07.05.2019 | River Plate | - | Guaraní | 0:1 | ||||
| 21. Jornada | 11.05.2019 | Guaraní | - | Sol de América | 3:1 | ||||
| 22. Jornada | 18.05.2019 | Club Olimpia | - | Guaraní | 2:0 |
Argentina