| 3. Jornada | 07.08.2021 | Lyngby BK | - | Esbjerg fB | 5:0 | ||||
| 4. Jornada | 13.08.2021 | Esbjerg fB | - | AC Horsens | 0:0 |  |
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| 6. Jornada | 20.08.2021 | Esbjerg fB | - | Hvidovre IF | 1:2 | ||||
| 7. Jornada | 27.08.2021 | Nykøbing FC | - | Esbjerg fB | 1:1 |  |
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| 9. Jornada | 18.09.2021 | Esbjerg fB | - | Fremad Amager | 2:1 | ||||
| 10. Jornada | 26.09.2021 | Jammerbugt FC | - | Esbjerg fB | 1:0 | ||||
| 11. Jornada | 04.10.2021 | Esbjerg fB | - | HB Køge | 2:0 |  |
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| 12. Jornada | 14.10.2021 | FC Helsingør | - | Esbjerg fB | 3:0 | ||||
| 13. Jornada | 23.10.2021 | Esbjerg fB | - | FC Fredericia | 1:2 | |
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| 14. Jornada | 29.10.2021 | Hobro IK | - | Esbjerg fB | 2:6 |  |
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| 17. Jornada | 28.11.2021 | Esbjerg fB | - | Nykøbing FC | 3:0 | |
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| 19. Jornada | 25.02.2022 | Fremad Amager | - | Esbjerg fB | 4:2 | |
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| 20. Jornada | 06.03.2022 | Vendsyssel FF | - | Esbjerg fB | 1:0 | |
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| 21. Jornada | 13.03.2022 | AC Horsens | - | Esbjerg fB | 0:0 |
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