| 1. Jornada | 14.08.2021 | RWD Molenbeek | - | Royal Excel Mouscron | 3:1 |  |
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| 2. Jornada | 20.08.2021 | KVC Westerlo | - | RWD Molenbeek | 0:0 | ||||
| 3. Jornada | 27.08.2021 | RWD Molenbeek | - | Excelsior Virton | 0:0 | ||||
| 5. Jornada | 17.09.2021 | RWD Molenbeek | - | Waasland-Beveren | 1:3 | ||||
| 6. Jornada | 25.09.2021 | RWD Molenbeek | - | Lommel SK | 1:2 | ||||
| 7. Jornada | 03.10.2021 | KMSK Deinze | - | RWD Molenbeek | 1:2 | |
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| 8. Jornada | 17.10.2021 | RWD Molenbeek | - | KVC Westerlo | 1:2 | ||||
| 9. Jornada | 22.10.2021 | Royal Excel Mouscron | - | RWD Molenbeek | 1:1 | ||||
| 11. Jornada | 07.11.2021 | RWD Molenbeek | - | Lierse Kempenzonen | 3:3 | ||||
| 12. Jornada | 21.11.2021 | Excelsior Virton | - | RWD Molenbeek | 0:2 | ||||
| 13. Jornada | 28.11.2021 | RWD Molenbeek | - | KMSK Deinze | 2:2 | ||||
| 17. Jornada | 21.01.2022 | RWD Molenbeek | - | Lommel SK | 2:0 | ||||
| 15. Jornada | 25.01.2022 | RWD Molenbeek | - | KVC Westerlo | 0:2 | ||||
| 19. Jornada | 06.02.2022 | Excelsior Virton | - | RWD Molenbeek | 0:1 | |
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| 20. Jornada | 13.02.2022 | RWD Molenbeek | - | KMSK Deinze | 1:0 | ||||
| 25. Jornada | 20.03.2022 | RWD Molenbeek | - | Excelsior Virton | 3:0 |
Francia