| 1. Jornada | 05.02.2022 | Montevideo City Torque | - | Cerro Largo | 1:1 |  |
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| 2. Jornada | 14.02.2022 | Montevideo Wanderers | - | Cerro Largo | 1:0 | ||||
| 3. Jornada | 19.02.2022 | Cerro Largo | - | Plaza Colonia | 0:5 | ||||
| 4. Jornada | 25.02.2022 | Boston River | - | Cerro Largo | 3:0 | |
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| 5. Jornada | 05.03.2022 | River Plate | - | Cerro Largo | 1:1 | ||||
| 6. Jornada | 22.03.2022 | Cerro Largo | - | Cerrito | 1:0 | ||||
| 9. Jornada | 16.04.2022 | Albion | - | Cerro Largo | 2:1 | |
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| 15. Jornada | 04.06.2022 | Peñarol | - | Cerro Largo | 0:1 | |
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Uruguay