| 2. Jornada | 13.03.2021 | Jorge Wilstermann | - | Nacional Potosí | 1:2 |  |
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| 1. Jornada | 28.03.2021 | Real Santa Cruz | - | Jorge Wilstermann | 0:2 | ||||
| 3. Jornada | 04.04.2021 | Oriente Petrolero | - | Jorge Wilstermann | 4:2 | ||||
| 4. Jornada | 11.04.2021 | Jorge Wilstermann | - | The Strongest | 0:3 | ||||
| 19. Jornada | 19.09.2021 | The Strongest | - | Jorge Wilstermann | 3:1 | ||||
| 20. Jornada | 24.09.2021 | Jorge Wilstermann | - | Independiente Petrolero | 2:3 | ||||
| 21. Jornada | 28.09.2021 | Jorge Wilstermann | - | Atlético Palmaflor | 5:0 | ||||
| 22. Jornada | 20.10.2021 | Always Ready | - | Jorge Wilstermann | 0:0 |  |
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| 23. Jornada | 23.10.2021 | Jorge Wilstermann | - | Royal Pari | 4:1 | ||||
| 24. Jornada | 27.10.2021 | Real Potosí | - | Jorge Wilstermann | 2:2 | |
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| 25. Jornada | 30.10.2021 | Jorge Wilstermann | - | CD Guabirá | 2:1 | ||||
| 26. Jornada | 22.11.2021 | Blooming | - | Jorge Wilstermann | 2:2 | |
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| 27. Jornada | 28.11.2021 | Jorge Wilstermann | - | Bolívar | 1:0 | ||||
| 28. Jornada | 02.12.2021 | Club Aurora | - | Jorge Wilstermann | 1:1 | ||||
| 29. Jornada | 07.12.2021 | Jorge Wilstermann | - | Real Tomayapo | 3:0 | |
Argentina