| 2. Jornada | 21.01.2021 | Montevideo Wanderers | - | Danubio | 2:0 | ||||
| 4. Jornada | 04.02.2021 | River Plate | - | Danubio | 0:4 | ||||
| 5. Jornada | 07.02.2021 | Danubio | - | Montevideo City Torque | 0:4 | ||||
| 6. Jornada | 10.02.2021 | Plaza Colonia | - | Danubio | 3:0 |  |
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| 7. Jornada | 15.02.2021 | Danubio | - | Progreso | 0:1 | ||||
| 9. Jornada | 22.02.2021 | Danubio | - | CA Cerro | 2:1 | ||||
| 10. Jornada | 28.02.2021 | Defensor Sporting | - | Danubio | 1:1 | ||||
| 12. Jornada | 13.03.2021 | Danubio | - | Nacional | 2:1 | ||||
| 13. Jornada | 19.03.2021 | Boston River | - | Danubio | 1:5 | ||||
| 14. Jornada | 23.03.2021 | Danubio | - | Deportivo Maldonado | 2:2 |
Uruguay