| 3. Jornada | 02.02.2021 | Real Santander | - | Atlético FC | 2:2 | ||||
| 4. Jornada | 06.02.2021 | Barranquilla FC | - | Real Santander | 1:0 | ||||
| 5. Jornada | 12.02.2021 | Real Santander | - | Valledupar FC | 0:1 | ||||
| 6. Jornada | 14.02.2021 | Llaneros FC | - | Real Santander | 0:0 |  |
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| 1. Jornada | 18.02.2021 | Real Santander | - | Atlético Huila | 2:2 | |
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| 7. Jornada | 21.02.2021 | Real Santander | - | Unión Magdalena | 0:1 | ||||
| 2. Jornada | 24.02.2021 | Cortuluá | - | Real Santander | 1:0 | ||||
| 8. Jornada | 01.03.2021 | Real Santander | - | Deportes Quindío | 1:1 | ||||
| 9. Jornada | 04.03.2021 | Real Santander | - | Orsomarso SC | 1:2 | ||||
| 10. Jornada | 07.03.2021 | Real Santander | - | Boca Juniors de Cali | 0:1 | ||||
| 11. Jornada | 14.03.2021 | Real Santander | - | Real Cartagena | 0:3 | |
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| 12. Jornada | 21.03.2021 | Tigres FC | - | Real Santander | 1:1 | ||||
| 13. Jornada | 27.03.2021 | Bogotá FC | - | Real Santander | 1:4 | ||||
| 14. Jornada | 03.04.2021 | Real Santander | - | Fortaleza FC | 3:1 | ||||
| 15. Jornada | 09.04.2021 | Leones FC | - | Real Santander | 2:0 |
Colombia