| 1. Jornada | 20.02.2021 | San Francisco FC | - | Atlético Chiriquí | 4:4 |  |
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| 2. Jornada | 27.02.2021 | UD Universitario | - | San Francisco FC | 3:2 | ||||
| 3. Jornada | 06.03.2021 | San Francisco FC | - | Independiente de La Chorrera | 0:1 | ||||
| 4. Jornada | 15.03.2021 | Herrera FC | - | San Francisco FC | 1:0 | ||||
| 11. Jornada | 15.04.2021 | Árabe Unido | - | San Francisco FC | 1:1 | |
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| 12. Jornada | 21.04.2021 | Atlético Chiriquí | - | San Francisco FC | 3:0 |
Colombia