| 1. Jornada | 09.08.2015 | Newcastle United | - | Southampton | 2:2 | ||||
| 4. Jornada | 30.08.2015 | Southampton | - | Norwich City | 3:0 | ||||
| 6. Jornada | 20.09.2015 | Southampton | - | Manchester United | 2:3 | ||||
| 18. Jornada | 26.12.2015 | Southampton | - | Arsenal | 4:0 |  |
|||
| 19. Jornada | 28.12.2015 | West Ham United | - | Southampton | 2:1 |  |
|||
| 20. Jornada | 02.01.2016 | Norwich City | - | Southampton | 1:0 | ||||
| 22. Jornada | 16.01.2016 | Southampton | - | West Bromwich Albion | 3:0 | ||||
| 29. Jornada | 05.03.2016 | Southampton | - | Sunderland | 1:1 | ||||
| 30. Jornada | 12.03.2016 | Stoke City | - | Southampton | 1:2 | ||||
| 31. Jornada | 20.03.2016 | Southampton | - | Liverpool | 3:2 | ||||
| 33. Jornada | 09.04.2016 | Southampton | - | Newcastle United | 3:1 | ||||
| 34. Jornada | 16.04.2016 | Everton | - | Southampton | 1:1 | ||||
| 36. Jornada | 01.05.2016 | Southampton | - | Manchester City | 4:2 | ||||
| 37. Jornada | 08.05.2016 | Tottenham Hotspur | - | Southampton | 1:2 | ||||
| 38. Jornada | 15.05.2016 | Southampton | - | Crystal Palace | 4:1 |
Países Bajos