| 2. Jornada | 25.07.2021 | HNK Rijeka | - | NK Istra 1961 | 2:0 | ||||
| 3. Jornada | 31.07.2021 | NK Istra 1961 | - | HNK Gorica | 1:2 | ||||
| 5. Jornada | 14.08.2021 | Lokomotiva Zagreb | - | NK Istra 1961 | 4:0 |  |
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| 6. Jornada | 22.08.2021 | NK Istra 1961 | - | NK Osijek | 2:0 | ||||
| 7. Jornada | 28.08.2021 | HNK Šibenik | - | NK Istra 1961 | 3:1 | |
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| 8. Jornada | 12.09.2021 | NK Istra 1961 | - | Hajduk Split | 1:3 | |
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| 10. Jornada | 27.09.2021 | Hrvatski Dragovoljac | - | NK Istra 1961 | 0:1 | ||||
| 11. Jornada | 02.10.2021 | NK Istra 1961 | - | HNK Rijeka | 3:6 | ||||
| 18. Jornada | 06.12.2021 | NK Istra 1961 | - | Slaven Belupo | 1:2 | ||||
| 19. Jornada | 10.12.2021 | NK Istra 1961 | - | Hrvatski Dragovoljac | 3:0 | ||||
| 4. Jornada | 15.12.2021 | NK Istra 1961 | - | Dinamo Zagreb | 0:2 | ||||
| 20. Jornada | 18.12.2021 | HNK Rijeka | - | NK Istra 1961 | 1:0 |
Croacia