| 1. Jornada | 18.09.2021 | Club Tijuana [] | - | Pumas UNAM [] | 1:2 | ||||
| 3. Jornada | 02.10.2021 | Deportivo Toluca [] | - | Club Tijuana [] | 3:0 | ||||
| 4. Jornada | 09.10.2021 | Club Tijuana [] | - | Puebla FC [] | 5:0 |  |
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| 7. Jornada | 30.10.2021 | Club Tijuana [] | - | Gallos Blancos [] | 3:0 | ||||
| 10. Jornada | 20.11.2021 | Club Tijuana [] | - | Cruz Azul [] | 1:2 |
México