| 4. Jornada | 14.08.2021 | Bohemians Praha 1905 | - | Sparta Praga | 1:1 | ||||
| 6. Jornada | 29.08.2021 | Bohemians Praha 1905 | - | FK Teplice | 4:2 |  |
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| 7. Jornada | 11.09.2021 | FC Fastav Zlín | - | Bohemians Praha 1905 | 1:3 | ||||
| 8. Jornada | 19.09.2021 | Bohemians Praha 1905 | - | Slavia Praga | 1:5 | ||||
| 9. Jornada | 25.09.2021 | Baník Ostrava | - | Bohemians Praha 1905 | 4:1 | ||||
| 10. Jornada | 02.10.2021 | Bohemians Praha 1905 | - | Sigma Olomouc | 2:0 | ||||
| 11. Jornada | 16.10.2021 | FK Mladá Boleslav | - | Bohemians Praha 1905 | 4:1 | ||||
| 12. Jornada | 23.10.2021 | 1. FC Slovácko | - | Bohemians Praha 1905 | 1:0 | ||||
| 19. Jornada | 18.12.2021 | Bohemians Praha 1905 | - | FK Pardubice | 1:2 | ||||
| 24. Jornada | 05.03.2022 | Sigma Olomouc | - | Bohemians Praha 1905 | 0:0 | ||||
| 25. Jornada | 12.03.2022 | Bohemians Praha 1905 | - | FK Mladá Boleslav | 2:2 | |
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| 26. Jornada | 19.03.2022 | Bohemians Praha 1905 | - | 1. FC Slovácko | 1:2 |
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