| 1. Jornada | 01.07.2021 | FC Floreşti | - | CS Petrocub | 0:1 | ||||
| 2. Jornada | 17.07.2021 | FC Zimbru | - | FC Floreşti | 4:0 |  |
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| 3. Jornada | 24.07.2021 | FC Floreşti | - | Dinamo-Auto | 0:1 | ||||
| 4. Jornada | 31.07.2021 | FC Floreşti | - | FC Sheriff | 1:3 | ||||
| 5. Jornada | 08.08.2021 | FC Milsami | - | FC Floreşti | 4:1 | ||||
| 6. Jornada | 15.08.2021 | FC Floreşti | - | FC Sfîntul Gheorghe | 1:5 | ||||
| 7. Jornada | 20.08.2021 | FC Bălţi | - | FC Floreşti | 3:1 | ||||
| 8. Jornada | 25.08.2021 | CS Petrocub | - | FC Floreşti | 2:0 | ||||
| 9. Jornada | 11.09.2021 | FC Floreşti | - | FC Zimbru | 1:3 | |
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| 10. Jornada | 18.09.2021 | Dinamo-Auto | - | FC Floreşti | 1:0 | ||||
| 11. Jornada | 22.09.2021 | FC Sheriff | - | FC Floreşti | 4:0 | ||||
| 12. Jornada | 26.09.2021 | FC Floreşti | - | FC Milsami | 0:3 | |
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| 14. Jornada | 16.10.2021 | FC Floreşti | - | FC Bălţi | 1:3 | ||||
| 15. Jornada | 23.10.2021 | FC Floreşti | - | CS Petrocub | 3:4 | ||||
| 17. Jornada | 06.11.2021 | FC Floreşti | - | Dinamo-Auto | 1:5 | ||||
| 18. Jornada | 20.11.2021 | FC Floreşti | - | FC Sheriff | 1:3 |
Moldavia