| 2. Jornada | 16.07.2022 | Real Cartagena | - | Leones FC | 0:1 | ||||
| 3. Jornada | 22.07.2022 | Atlético Huila | - | Real Cartagena | 2:3 | ||||
| 4. Jornada | 29.07.2022 | Real Cartagena | - | Cúcuta Deportivo | 1:2 | ||||
| 5. Jornada | 04.08.2022 | Real Cartagena | - | Orsomarso SC | 0:1 |  |
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| 6. Jornada | 07.08.2022 | Fortaleza FC | - | Real Cartagena | 3:1 | ||||
| 7. Jornada | 17.08.2022 | Real Cartagena | - | Real Santander | 2:2 | ||||
| 9. Jornada | 31.08.2022 | Real Cartagena | - | Barranquilla FC | 2:2 | |
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| 10. Jornada | 03.09.2022 | Valledupar FC | - | Real Cartagena | 1:1 | ||||
| 11. Jornada | 07.09.2022 | Real Cartagena | - | Tigres FC | 0:1 | ||||
| 12. Jornada | 11.09.2022 | Llaneros FC | - | Real Cartagena | 2:0 | ||||
| 1. Jornada | 15.09.2022 | Atlético FC | - | Real Cartagena | 0:2 | ||||
| 16. Jornada | 08.10.2022 | Bogotá FC | - | Real Cartagena | 2:0 |
Colombia