| 3. Jornada | 06.08.2021 | Real Cartagena | - | Fortaleza FC | 0:1 |  |
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| 4. Jornada | 14.08.2021 | Real Santander | - | Real Cartagena | 2:2 | ||||
| 5. Jornada | 25.08.2021 | Real Cartagena | - | Cortuluá | 2:0 | ||||
| 6. Jornada | 31.08.2021 | Unión Magdalena | - | Real Cartagena | 1:0 | |
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| 7. Jornada | 04.09.2021 | Real Cartagena | - | Boca Juniors de Cali | 2:0 | |
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| 9. Jornada | 19.09.2021 | Leones FC | - | Real Cartagena | 2:0 | |
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| 12. Jornada | 12.10.2021 | Real Cartagena | - | Barranquilla FC | 3:1 | ||||
| 15. Jornada | 30.10.2021 | Orsomarso SC | - | Real Cartagena | 1:1 |
Colombia