| 9. Jornada | 18.04.2022 | San Luis | - | Deportes Melipilla | 2:1 | ||||
| 12. Jornada | 30.04.2022 | San Luis | - | Deportes Temuco | 1:1 | ||||
| 14. Jornada | 13.05.2022 | San Luis | - | Fernández Vial | 0:0 | ||||
| 15. Jornada | 18.05.2022 | Santa Cruz | - | San Luis | 2:0 |  |
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| 16. Jornada | 24.05.2022 | Recoleta | - | San Luis | 2:3 | ||||
| 17. Jornada | 01.06.2022 | San Luis | - | Universidad de Concepción | 0:2 | ||||
| 18. Jornada | 05.07.2022 | San Luis | - | Cobreloa | 0:0 | ||||
| 21. Jornada | 26.07.2022 | Santiago Wanderers | - | San Luis | 1:2 | ||||
| 29. Jornada | 27.09.2022 | Deportes Temuco | - | San Luis | 1:0 |  |
Chile