| 1. Jornada | 17.01.2021 | Progreso | - | Montevideo City Torque | 0:0 | ||||
| 4. Jornada | 02.02.2021 | Progreso | - | Fénix | 0:1 |  |
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| 5. Jornada | 07.02.2021 | CA Cerro | - | Progreso | 2:0 | ||||
| 6. Jornada | 11.02.2021 | Progreso | - | Defensor Sporting | 3:3 | ||||
| 7. Jornada | 15.02.2021 | Danubio | - | Progreso | 0:1 | |
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| 8. Jornada | 18.02.2021 | Progreso | - | Nacional | 0:1 | ||||
| 9. Jornada | 23.02.2021 | Boston River | - | Progreso | 2:3 | ||||
| 10. Jornada | 02.03.2021 | Progreso | - | Deportivo Maldonado | 1:1 | ||||
| 13. Jornada | 21.03.2021 | Montevideo Wanderers | - | Progreso | 3:0 | ||||
| 14. Jornada | 25.03.2021 | Progreso | - | Peñarol | 0:2 |
Uruguay