| 5. Jornada | 03.10.2021 | Ionikos Nikea | - | Lamia | 1:2 | ||||
| 6. Jornada | 18.10.2021 | Lamia | - | Aris Saloniki | 0:1 |  |
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| 7. Jornada | 24.10.2021 | OFI Heraklion | - | Lamia | 0:0 | |
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| 8. Jornada | 31.10.2021 | Lamia | - | Atromitos | 2:2 | ||||
| 9. Jornada | 07.11.2021 | Asteras Tripolis | - | Lamia | 0:1 | |
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| 10. Jornada | 22.11.2021 | Lamia | - | Panathinaikos | 1:3 | ||||
| 11. Jornada | 27.11.2021 | Apollon Smyrnis | - | Lamia | 0:0 | |
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| 12. Jornada | 06.12.2021 | Lamia | - | PAS Giannina | 0:1 | ||||
| 13. Jornada | 12.12.2021 | PAOK Saloniki | - | Lamia | 2:1 | |
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| 14. Jornada | 15.12.2021 | Lamia | - | Volos NFC | 2:2 |  |
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| 16. Jornada | 05.01.2022 | Lamia | - | AEK Athen | 0:2 | ||||
| 18. Jornada | 15.01.2022 | Lamia | - | Ionikos Nikea | 2:1 | ||||
| 19. Jornada | 23.01.2022 | Aris Saloniki | - | Lamia | 0:0 | ||||
| 20. Jornada | 29.01.2022 | Lamia | - | OFI Heraklion | 2:1 | |
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| 17. Jornada | 16.02.2022 | Panetolikos | - | Lamia | 1:0 | ||||
| 24. Jornada | 20.02.2022 | Lamia | - | Apollon Smyrnis | 1:2 | ||||
| 22. Jornada | 23.02.2022 | Lamia | - | Asteras Tripolis | 0:2 | ||||
| 25. Jornada | 28.02.2022 | PAS Giannina | - | Lamia | 1:0 | ||||
| 26. Jornada | 06.03.2022 | Lamia | - | PAOK Saloniki | 0:2 |
Bolivia