| 18. Jornada | 13.02.2021 | HNK Orijent Rijeka | - | NK Osijek II | 3:0 | ||||
| 20. Jornada | 28.02.2021 | NK Croatia Zmijavci | - | NK Osijek II | 1:0 |  |
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| 21. Jornada | 06.03.2021 | NK Junak Sinj | - | NK Osijek II | 1:1 | ||||
| 22. Jornada | 13.03.2021 | NK Osijek II | - | NK Dugopolje | 2:0 |  |
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| 23. Jornada | 19.03.2021 | NK Međimurje | - | NK Osijek II | 0:1 | ||||
| 24. Jornada | 02.04.2021 | NK Osijek II | - | NK Inter Zaprešić | 1:2 | ||||
| 25. Jornada | 10.04.2021 | NK Kustošija | - | NK Osijek II | 1:0 | ||||
| 26. Jornada | 17.04.2021 | NK Osijek II | - | NK Opatija | 1:0 | ||||
| 28. Jornada | 24.04.2021 | NK Osijek II | - | NK BSK Bijelo Brdo | 3:0 | ||||
| 27. Jornada | 28.04.2021 | Dinamo Zagreb II | - | NK Osijek II | 3:0 | ||||
| 29. Jornada | 02.05.2021 | Hajduk Split II | - | NK Osijek II | 4:3 | ||||
| 31. Jornada | 12.05.2021 | NK Solin | - | NK Osijek II | 4:3 | ||||
| 32. Jornada | 16.05.2021 | NK Osijek II | - | NK Rudeš | 2:3 | ||||
| 34. Jornada | 29.05.2021 | NK Osijek II | - | NK Dubrava | 0:5 |
Croacia