| 1. Jornada | 08.08.2021 | Makedonija GP | - | FK Pelister | 1:0 |  |
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| 2. Jornada | 15.08.2021 | FC Struga | - | FK Pelister | 1:0 | ||||
| 3. Jornada | 18.08.2021 | FK Pelister | - | KF Shkupi | 0:2 | ||||
| 4. Jornada | 22.08.2021 | FK Skopje | - | FK Pelister | 1:0 | |
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| 5. Jornada | 28.08.2021 | FK Pelister | - | KF Shkëndija 79 | 2:2 | |
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| 6. Jornada | 12.09.2021 | FK Borec | - | FK Pelister | 2:1 | ||||
| 7. Jornada | 19.09.2021 | FK Pelister | - | FK AP Brera Strumica | 0:0 | ||||
| 8. Jornada | 26.09.2021 | FK Rabotnički | - | FK Pelister | 1:1 | ||||
| 9. Jornada | 02.10.2021 | FK Pelister | - | GFK Tikvesh | 0:0 | ||||
| 10. Jornada | 16.10.2021 | FK Renova | - | FK Pelister | 2:0 |  |
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| 12. Jornada | 30.10.2021 | FK Pelister | - | Makedonija GP | 0:2 | ||||
| 13. Jornada | 06.11.2021 | FK Pelister | - | FC Struga | 0:1 | ||||
| 14. Jornada | 21.11.2021 | KF Shkupi | - | FK Pelister | 5:0 | ||||
| 15. Jornada | 28.11.2021 | FK Pelister | - | FK Skopje | 0:0 | ||||
| 16. Jornada | 05.12.2021 | KF Shkëndija 79 | - | FK Pelister | 2:1 | ||||
| 17. Jornada | 08.12.2021 | FK Pelister | - | FK Borec | 1:3 |  |
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Macedonia del Norte