| 1. Jornada | 13.01.2022 | Santos Laguna | - | UANL Tigres | 1:1 | ||||
| 3. Jornada | 24.01.2022 | Santos Laguna | - | Club Necaxa | 1:4 | ||||
| 7. Jornada | 28.02.2022 | Cruz Azul | - | Santos Laguna | 1:2 | ||||
| 8. Jornada | 03.03.2022 | Santos Laguna | - | Pumas UNAM | 3:2 |  |
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| 10. Jornada | 14.03.2022 | Santos Laguna | - | Club Tijuana | 4:0 | ||||
| 11. Jornada | 19.03.2022 | Puebla FC | - | Santos Laguna | 2:2 | ||||
| 14. Jornada | 17.04.2022 | Santos Laguna | - | Gallos Blancos | 1:1 | ||||
| 15. Jornada | 20.04.2022 | Mazatlán FC | - | Santos Laguna | 1:0 | ||||
| 16. Jornada | 25.04.2022 | Santos Laguna | - | Club León | 1:1 | ||||
| 17. Jornada | 01.05.2022 | Atlético San Luis | - | Santos Laguna | 1:3 |
México