| 1. Jornada | 24.07.2021 | MFK Ružomberok | - | FK Senica | 0:0 | ||||
| 2. Jornada | 01.08.2021 | FK Senica | - | Spartak Trnava | 2:1 | ||||
| 3. Jornada | 06.08.2021 | Zlaté Moravce | - | FK Senica | 1:1 | ||||
| 4. Jornada | 14.08.2021 | FK Senica | - | FC DAC 1904 | 1:1 | ||||
| 5. Jornada | 22.08.2021 | MŠK Žilina | - | FK Senica | 3:0 | ||||
| 6. Jornada | 28.08.2021 | Tatran Liptovský Mikuláš | - | FK Senica | 1:2 | ||||
| 7. Jornada | 11.09.2021 | FK Senica | - | FK Pohronie | 1:0 | ||||
| 8. Jornada | 18.09.2021 | AS Trenčín | - | FK Senica | 3:3 |  |
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| 9. Jornada | 25.09.2021 | FK Senica | - | Slovan Bratislava | 0:3 | |
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| 10. Jornada | 02.10.2021 | ŠKF Sereď | - | FK Senica | 2:1 | ||||
| 11. Jornada | 16.10.2021 | FK Senica | - | MFK Zemplín Michalovce | 1:1 | ||||
| 12. Jornada | 23.10.2021 | FK Senica | - | MFK Ružomberok | 0:2 |  |
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| 14. Jornada | 06.11.2021 | FK Senica | - | Zlaté Moravce | 1:2 | ||||
| 15. Jornada | 20.11.2021 | FC DAC 1904 | - | FK Senica | 1:0 | ||||
| 16. Jornada | 30.11.2021 | FK Senica | - | MŠK Žilina | 2:2 | |
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| 17. Jornada | 04.12.2021 | FK Senica | - | Tatran Liptovský Mikuláš | 1:0 | ||||
| 18. Jornada | 11.12.2021 | FK Pohronie | - | FK Senica | 0:1 | ||||
| 19. Jornada | 18.12.2021 | FK Senica | - | AS Trenčín | 1:0 |
República Checa