| 1. Jornada | 28.07.2021 | Real Cartagena | - | Valledupar FC | 2:2 | ||||
| 2. Jornada | 31.07.2021 | Valledupar FC | - | Leones FC | 1:1 | ||||
| 3. Jornada | 09.08.2021 | Llaneros FC | - | Valledupar FC | 1:0 | ||||
| 4. Jornada | 15.08.2021 | Valledupar FC | - | Tigres FC | 0:0 | ||||
| 5. Jornada | 26.08.2021 | Barranquilla FC | - | Valledupar FC | 2:1 | ||||
| 6. Jornada | 30.08.2021 | Valledupar FC | - | Bogotá FC | 0:2 | ||||
| 11. Jornada | 03.10.2021 | Valledupar FC | - | Fortaleza FC | 1:1 | ||||
| 12. Jornada | 09.10.2021 | Real Santander | - | Valledupar FC | 1:1 | ||||
| 13. Jornada | 19.10.2021 | Valledupar FC | - | Cortuluá | 1:2 | ||||
| 14. Jornada | 24.10.2021 | Unión Magdalena | - | Valledupar FC | 3:1 | ||||
| 15. Jornada | 30.10.2021 | Valledupar FC | - | Boca Juniors de Cali | 2:1 |
Colombia