| 4. Jornada | 06.02.2022 | Atlas Guadalajara [Sub 20] | - | Santos Laguna [Sub 20] | 0:1 |  |
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| 5. Jornada | 12.02.2022 | Santos Laguna [Sub 20] | - | CF América [Sub 20] | 0:0 | ||||
| 8. Jornada | 02.03.2022 | Santos Laguna [Sub 20] | - | Pumas UNAM [Sub 20] | 2:1 | |
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| 13. Jornada | 26.03.2022 | CF Monterrey [Sub 20] | - | Santos Laguna [Sub 20] | 1:2 |
México