| 2. Jornada | 08.07.2022 | Puebla FC [Sub 20] | - | Santos Laguna [Sub 20] | 2:2 | ||||
| 7. Jornada | 06.08.2022 | Santos Laguna [Sub 20] | - | Cruz Azul [Sub 20] | 2:1 | ||||
| 9. Jornada | 18.08.2022 | Santos Laguna [Sub 20] | - | Club León [Sub 20] | 2:3 | ||||
| 11. Jornada | 28.08.2022 | Santos Laguna [Sub 20] | - | Atlético San Luis [Sub 20] | 7:2 | ||||
| 4. Jornada | 22.09.2022 | Deportivo Toluca [Sub 20] | - | Santos Laguna [Sub 20] | 1:0 | ||||
| 17. Jornada | 02.10.2022 | Santos Laguna [Sub 20] | - | Mazatlán FC [Sub 20] | 2:3 |
México