| 8. Jornada | 11.09.2021 | NK Celje | - | NK Domžale | 3:1 | ||||
| 9. Jornada | 18.09.2021 | NK Domžale | - | NK Radomlje | 2:0 |  |
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| 10. Jornada | 22.09.2021 | Olimpija Ljubljana | - | NK Domžale | 2:1 | ||||
| 11. Jornada | 26.09.2021 | NK Domžale | - | NK Maribor | 3:3 | ||||
| 4. Jornada | 29.09.2021 | FC Koper | - | NK Domžale | 4:2 | ||||
| 12. Jornada | 02.10.2021 | NK Tabor Sežana | - | NK Domžale | 0:0 |  |
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| 13. Jornada | 17.10.2021 | NK Domžale | - | FC Koper | 2:3 | |
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| 14. Jornada | 23.10.2021 | NK Bravo | - | NK Domžale | 0:1 | |
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| 15. Jornada | 31.10.2021 | NK Domžale | - | NK Aluminij | 1:1 | ||||
| 16. Jornada | 07.11.2021 | NŠ Mura | - | NK Domžale | 1:1 | |
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| 17. Jornada | 22.11.2021 | NK Domžale | - | NK Celje | 1:0 | ||||
| 18. Jornada | 27.11.2021 | NK Radomlje | - | NK Domžale | 0:2 | |
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| 20. Jornada | 11.12.2021 | NK Maribor | - | NK Domžale | 1:0 | ||||
| 26. Jornada | 09.03.2022 | NK Celje | - | NK Domžale | 2:1 | ||||
| 30. Jornada | 10.04.2022 | NK Tabor Sežana | - | NK Domžale | 2:1 | ||||
| 31. Jornada | 16.04.2022 | NK Domžale | - | FC Koper | 0:1 | ||||
| 32. Jornada | 24.04.2022 | NK Bravo | - | NK Domžale | 0:2 | ||||
| 33. Jornada | 01.05.2022 | NK Domžale | - | NK Aluminij | 3:1 |
Serbia