| 9. Jornada | 11.09.2021 | FC Floreşti | - | FC Zimbru | 1:3 | ||||
| 10. Jornada | 18.09.2021 | Dinamo-Auto | - | FC Floreşti | 1:0 | ||||
| 11. Jornada | 22.09.2021 | FC Sheriff | - | FC Floreşti | 4:0 | ||||
| 12. Jornada | 26.09.2021 | FC Floreşti | - | FC Milsami | 0:3 |  |
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| 13. Jornada | 01.10.2021 | FC Sfîntul Gheorghe | - | FC Floreşti | 4:1 | ||||
| 14. Jornada | 16.10.2021 | FC Floreşti | - | FC Bălţi | 1:3 | ||||
| 15. Jornada | 23.10.2021 | FC Floreşti | - | CS Petrocub | 3:4 | ||||
| 16. Jornada | 30.10.2021 | FC Zimbru | - | FC Floreşti | 3:0 | ||||
| 17. Jornada | 06.11.2021 | FC Floreşti | - | Dinamo-Auto | 1:5 | ||||
| 19. Jornada | 28.11.2021 | FC Milsami | - | FC Floreşti | 5:0 |
Moldavia