| 2. Jornada | 24.08.2021 | Chippa United | - | Mamelodi Sundowns | 0:0 | ||||
| 3. Jornada | 12.09.2021 | Mamelodi Sundowns | - | Kaizer Chiefs | 2:0 | ||||
| 4. Jornada | 19.09.2021 | Mamelodi Sundowns | - | TS Galaxy | 3:0 | ||||
| 5. Jornada | 25.09.2021 | Orlando Pirates | - | Mamelodi Sundowns | 0:2 | ||||
| 6. Jornada | 03.10.2021 | Mamelodi Sundowns | - | Moroka Swallows | 3:0 | ||||
| 7. Jornada | 20.10.2021 | Golden Arrows | - | Mamelodi Sundowns | 0:1 | ||||
| 11. Jornada | 20.11.2021 | Cape Town City FC | - | Mamelodi Sundowns | 0:0 | ||||
| 19. Jornada | 24.11.2021 | Mamelodi Sundowns | - | SuperSport United | 2:2 | ||||
| 12. Jornada | 27.11.2021 | Mamelodi Sundowns | - | Sekhukhune United | 2:0 |  |
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| 15. Jornada | 11.12.2021 | SuperSport United | - | Mamelodi Sundowns | 0:1 | ||||
| 22. Jornada | 14.12.2021 | Mamelodi Sundowns | - | Baroka FC | 2:1 | ||||
| 16. Jornada | 17.12.2021 | Mamelodi Sundowns | - | Orlando Pirates | 4:1 | ||||
| 17. Jornada | 20.12.2021 | AmaZulu FC | - | Mamelodi Sundowns | 1:0 | ||||
| 8. Jornada | 14.02.2022 | Baroka FC | - | Mamelodi Sundowns | 1:1 | ||||
| 25. Jornada | 12.04.2022 | Mamelodi Sundowns | - | Golden Arrows | 6:0 | ||||
| 26. Jornada | 27.04.2022 | Mamelodi Sundowns | - | Cape Town City FC | 0:0 |
Uganda