| 1. Jornada | 17.07.2022 | MFK Skalica | - | MFK Ružomberok | 0:2 | ||||
| 2. Jornada | 22.07.2022 | Zlaté Moravce | - | MFK Skalica | 2:2 | ||||
| 3. Jornada | 30.07.2022 | MFK Skalica | - | AS Trenčín | 2:0 |  |
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| 4. Jornada | 07.08.2022 | Slovan Bratislava | - | MFK Skalica | 3:0 | ||||
| 5. Jornada | 12.08.2022 | MFK Skalica | - | FK Železiarne Podbrezová | 1:1 | ||||
| 7. Jornada | 27.08.2022 | MFK Skalica | - | Spartak Trnava | 1:1 | ||||
| 9. Jornada | 03.09.2022 | Tatran Liptovský Mikuláš | - | MFK Skalica | 0:0 | ||||
| 10. Jornada | 10.09.2022 | MFK Skalica | - | FC DAC 1904 | 1:1 | |
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| 12. Jornada | 30.09.2022 | MFK Ružomberok | - | MFK Skalica | 2:0 | ||||
| 13. Jornada | 08.10.2022 | MFK Skalica | - | Zlaté Moravce | 0:2 | ||||
| 14. Jornada | 15.10.2022 | AS Trenčín | - | MFK Skalica | 3:1 | ||||
| 15. Jornada | 21.10.2022 | MFK Skalica | - | Slovan Bratislava | 1:4 | ||||
| 16. Jornada | 29.10.2022 | FK Železiarne Podbrezová | - | MFK Skalica | 0:2 | |
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| 17. Jornada | 05.11.2022 | MFK Skalica | - | MFK Zemplín Michalovce | 0:0 | ||||
| 18. Jornada | 11.11.2022 | Spartak Trnava | - | MFK Skalica | 2:1 |
Eslovaquia