| 10. Jornada | 02.10.2021 | Port Vale FC | - | Leyton Orient | 3:2 |  |
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| 12. Jornada | 16.10.2021 | Port Vale FC | - | Barrow AFC | 3:1 | |
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| 13. Jornada | 19.10.2021 | Mansfield Town | - | Port Vale FC | 1:1 | ||||
| 14. Jornada | 23.10.2021 | Port Vale FC | - | Colchester United | 3:0 | ||||
| 15. Jornada | 30.10.2021 | Crawley Town | - | Port Vale FC | 1:4 | ||||
| 17. Jornada | 20.11.2021 | Oldham Athletic | - | Port Vale FC | 3:2 | ||||
| 18. Jornada | 23.11.2021 | Port Vale FC | - | Walsall FC | 0:1 | ||||
| 20. Jornada | 07.12.2021 | Bristol Rovers | - | Port Vale FC | 1:2 |  |
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| 21. Jornada | 11.12.2021 | Newport County | - | Port Vale FC | 2:1 | ||||
| 27. Jornada | 15.01.2022 | Port Vale FC | - | Swindon Town | 1:3 |
Rumania