| 5. Jornada | 18.08.2021 | Club Tijuana [Sub 20] | - | Puebla FC [Sub 20] | 3:0 | ||||
| 6. Jornada | 22.08.2021 | Pumas UNAM [Sub 20] | - | Puebla FC [Sub 20] | 1:3 | ||||
| 16. Jornada | 29.10.2021 | FC Juárez [Sub 20] | - | Puebla FC [Sub 20] | 1:1 | ||||
| 17. Jornada | 05.11.2021 | Puebla FC [Sub 20] | - | Deportivo Toluca [Sub 20] | 0:3 |
México