| 1. Jornada | 18.07.2010 | Club Olimpia | - | Sport Colombia | 3:0 | ||||
| 2. Jornada | 25.07.2010 | Club Nacional | - | Club Olimpia | 0:2 |  |
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| 3. Jornada | 31.07.2010 | Club Olimpia | - | Club Rubio Ñu | 1:4 |  |
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| 6. Jornada | 22.08.2010 | Club Olimpia | - | Cerro Porteño | 2:2 | ||||
| 7. Jornada | 29.08.2010 | Club Olimpia | - | 3 de Febrero | 2:0 | |
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| 8. Jornada | 05.09.2010 | Sportivo Luqueño | - | Club Olimpia | 0:0 |  |
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| 9. Jornada | 12.09.2010 | Club Olimpia | - | Guaraní | 2:2 | ||||
| 10. Jornada | 19.09.2010 | Tacuary | - | Club Olimpia | 1:4 | |
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| 11. Jornada | 26.09.2010 | Sportivo Trinidense | - | Club Olimpia | 1:2 | ||||
| 12. Jornada | 03.10.2010 | Sport Colombia | - | Club Olimpia | 0:0 | ||||
| 14. Jornada | 17.10.2010 | Club Rubio Ñu | - | Club Olimpia | 2:2 | ||||
| 16. Jornada | 24.10.2010 | Libertad | - | Club Olimpia | 2:2 | ||||
| 17. Jornada | 31.10.2010 | Cerro Porteño | - | Club Olimpia | 1:1 | ||||
| 18. Jornada | 06.11.2010 | 3 de Febrero | - | Club Olimpia | 0:3 | ||||
| 19. Jornada | 12.11.2010 | Club Olimpia | - | Sportivo Luqueño | 1:1 | ||||
| 20. Jornada | 21.11.2010 | Guaraní | - | Club Olimpia | 0:0 | |
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| 21. Jornada | 27.11.2010 | Club Olimpia | - | Tacuary | 2:1 |
Paraguay