| 16. Jornada | 12.02.2022 | NK Osijek II | - | NK Sesvete | 0:3 | ||||
| 17. Jornada | 20.02.2022 | Dinamo Zagreb II | - | NK Osijek II | 2:1 |  |
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| 18. Jornada | 26.02.2022 | NK Osijek II | - | NK Dugopolje | 2:0 | ||||
| 20. Jornada | 14.03.2022 | NK Osijek II | - | NK Dubrava | 0:1 | ||||
| 22. Jornada | 04.04.2022 | NK Osijek II | - | HNK Orijent Rijeka | 1:0 | ||||
| 23. Jornada | 09.04.2022 | NK Opatija | - | NK Osijek II | 1:2 | ||||
| 24. Jornada | 15.04.2022 | NK Osijek II | - | HNK Cibalia | 2:1 | ||||
| 25. Jornada | 23.04.2022 | NK Varaždin | - | NK Osijek II | 4:1 | ||||
| 27. Jornada | 07.05.2022 | NK Rudeš | - | NK Osijek II | 1:0 | ||||
| 28. Jornada | 16.05.2022 | NK Osijek II | - | NK Kustošija | 0:1 | ||||
| 29. Jornada | 21.05.2022 | NK Jarun | - | NK Osijek II | 3:0 | ||||
| 30. Jornada | 28.05.2022 | NK Osijek II | - | NK BSK Bijelo Brdo | 1:1 |
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