| 20. Jornada | 07.09.2021 | Deportes Melipilla | - | Unión Española | 0:3 | ||||
| 22. Jornada | 25.09.2021 | Deportes Melipilla | - | Audax Italiano | 1:1 | ||||
| 23. Jornada | 30.09.2021 | Universidad Católica | - | Deportes Melipilla | 4:0 | ||||
| 24. Jornada | 04.10.2021 | Deportes Melipilla | - | Santiago Wanderers | 1:1 |  |
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| 27. Jornada | 20.10.2021 | O'Higgins | - | Deportes Melipilla | 1:2 |  |
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| 30. Jornada | 03.11.2021 | Deportes Melipilla | - | Cobresal | 2:1 |
Chile