| 1. Jornada | 10.07.2022 | Managua FC | - | Club Deportivo Ocotal | 3:1 | ||||
| 3. Jornada | 25.07.2022 | Managua FC | - | CD Walter Ferretti | 1:2 | ||||
| 5. Jornada | 07.08.2022 | Diriangén FC | - | Managua FC | 0:0 | ||||
| 8. Jornada | 21.08.2022 | Matagalpa FC | - | Managua FC | 1:0 | ||||
| 4. Jornada | 25.08.2022 | Managua FC | - | ART Municipal Jalapa | 1:1 | ||||
| 9. Jornada | 29.08.2022 | Managua FC | - | UNAN Managua | 2:1 | ||||
| 10. Jornada | 04.09.2022 | Club Deportivo Ocotal | - | Managua FC | 2:1 |  |
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| 11. Jornada | 12.09.2022 | Managua FC | - | Juventus Managua | 3:0 | |
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| 12. Jornada | 02.10.2022 | CD Walter Ferretti | - | Managua FC | 2:1 | |
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| 14. Jornada | 27.10.2022 | Managua FC | - | Diriangén FC | 1:2 | |
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| 15. Jornada | 30.10.2022 | Real Estelí FC | - | Managua FC | 2:2 | ||||
| 16. Jornada | 24.11.2022 | Managua FC | - | H&H Export Sébaco | 0:1 | ||||
| 17. Jornada | 27.11.2022 | Managua FC | - | Matagalpa FC | 2:1 | ||||
| 18. Jornada | 01.12.2022 | UNAN Managua | - | Managua FC | 1:3 |
Paraguay