| 1. Jornada | 01.08.2021 | Once Municipal | - | CD Águila | 2:2 | ||||
| 6. Jornada | 25.08.2021 | Luis Ángel Firpo | - | Once Municipal | 2:2 | ||||
| 5. Jornada | 10.09.2021 | Alianza | - | Once Municipal | 1:0 | ||||
| 9. Jornada | 16.09.2021 | Isidro Metapán | - | Once Municipal | 0:1 | ||||
| 10. Jornada | 19.09.2021 | Once Municipal | - | Atlético Marte | 0:0 | ||||
| 14. Jornada | 09.10.2021 | Municipal Limeño | - | Once Municipal | 1:1 | ||||
| 16. Jornada | 30.10.2021 | Once Municipal | - | Alianza | 2:3 |  |
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| 17. Jornada | 02.11.2021 | Once Municipal | - | Luis Ángel Firpo | 1:0 | ||||
| 18. Jornada | 07.11.2021 | Once Municipal | - | AD Chalatenango | 1:2 | ||||
| 19. Jornada | 14.11.2021 | FAS | - | Once Municipal | 3:2 | ||||
| 22. Jornada | 27.11.2021 | Once Municipal | - | Santa Tecla FC | 4:3 | |
El Salvador