| 1. Jornada | 01.08.2021 | Isidro Metapán | - | Atlético Marte | 0:0 | ||||
| 5. Jornada | 22.08.2021 | Isidro Metapán | - | Municipal Limeño | 1:0 | ||||
| 6. Jornada | 25.08.2021 | Platense Zacatecoluca | - | Isidro Metapán | 2:1 | ||||
| 7. Jornada | 29.08.2021 | Isidro Metapán | - | Alianza | 1:2 | ||||
| 8. Jornada | 12.09.2021 | Luis Ángel Firpo | - | Isidro Metapán | 1:1 | ||||
| 9. Jornada | 16.09.2021 | Isidro Metapán | - | Once Municipal | 0:1 | ||||
| 10. Jornada | 19.09.2021 | FAS | - | Isidro Metapán | 3:0 | ||||
| 11. Jornada | 26.09.2021 | Isidro Metapán | - | AD Chalatenango | 1:4 | ||||
| 12. Jornada | 02.10.2021 | Atlético Marte | - | Isidro Metapán | 2:0 |  |
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| 13. Jornada | 17.10.2021 | Isidro Metapán | - | Santa Tecla FC | 1:1 | ||||
| 14. Jornada | 21.10.2021 | CD Águila | - | Isidro Metapán | 4:0 | |
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| 16. Jornada | 30.10.2021 | Municipal Limeño | - | Isidro Metapán | 2:2 | |
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| 17. Jornada | 03.11.2021 | Isidro Metapán | - | Platense Zacatecoluca | 1:0 | |
El Salvador