| 3. Jornada | 22.01.2021 | Puebla FC [Sub 20] | - | Club Tijuana [Sub 20] | 0:2 | ||||
| 5. Jornada | 06.02.2021 | CF América [Sub 20] | - | Puebla FC [Sub 20] | 4:1 | ||||
| 6. Jornada | 12.02.2021 | Puebla FC [Sub 20] | - | FC Juárez [Sub 20] | 3:0 | ||||
| 9. Jornada | 02.03.2021 | Club León [Sub 20] | - | Puebla FC [Sub 20] | 2:1 | ||||
| 11. Jornada | 12.03.2021 | Puebla FC [Sub 20] | - | Atlas Guadalajara [Sub 20] | 0:5 | ||||
| 13. Jornada | 02.04.2021 | Puebla FC [Sub 20] | - | Mazatlán FC [Sub 20] | 6:2 | ||||
| 4. Jornada | 07.04.2021 | Puebla FC [Sub 20] | - | CF Monterrey [Sub 20] | 2:3 | ||||
| 15. Jornada | 17.04.2021 | Atlético San Luis [Sub 20] | - | Puebla FC [Sub 20] | 5:3 | ||||
| 16. Jornada | 23.04.2021 | Puebla FC [Sub 20] | - | Pumas UNAM [Sub 20] | 3:2 | ||||
| 17. Jornada | 02.05.2021 | Santos Laguna [Sub 20] | - | Puebla FC [Sub 20] | 2:3 |
México