| 2. Jornada | 13.01.2019 | Santos Laguna [Sub 20] | - | Monarcas Morelia [Sub 20] | 1:0 | ||||
| 3. Jornada | 18.01.2019 | Puebla FC [Sub 20] | - | Santos Laguna [Sub 20] | 1:1 | ||||
| 4. Jornada | 27.01.2019 | Santos Laguna [Sub 20] | - | Deportivo Guadalajara [Sub 20] | 7:3 | ||||
| 5. Jornada | 02.02.2019 | UANL Tigres [Sub 20] | - | Santos Laguna [Sub 20] | 1:1 |  |
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| 6. Jornada | 10.02.2019 | Santos Laguna [Sub 20] | - | Club Tijuana [Sub 20] | 3:1 | ||||
| 8. Jornada | 24.02.2019 | Santos Laguna [Sub 20] | - | Deportivo Toluca [Sub 20] | 2:0 | ||||
| 9. Jornada | 02.03.2019 | Club León [Sub 20] | - | Santos Laguna [Sub 20] | 2:1 |  |
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| 10. Jornada | 08.03.2019 | CD Veracruz [Sub 20] | - | Santos Laguna [Sub 20] | 0:1 | |
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| 11. Jornada | 17.03.2019 | Santos Laguna [Sub 20] | - | Club Necaxa [Sub 20] | 2:0 | |
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| 13. Jornada | 07.04.2019 | Santos Laguna [Sub 20] | - | CF Pachuca [Sub 20] | 1:5 | ||||
| 15. Jornada | 10.04.2019 | Santos Laguna [Sub 20] | - | Gallos Blancos [Sub 20] | 3:1 |
México