| 4. Jornada | 26.01.2021 | Guadalupe | - | Deportivo Saprissa | 2:2 | ||||
| 5. Jornada | 01.02.2021 | Santos de Guápiles | - | Guadalupe | 2:2 | ||||
| 7. Jornada | 06.02.2021 | Guadalupe | - | Sporting FC | 0:0 | ||||
| 8. Jornada | 16.02.2021 | Municipal Pérez Zeledón | - | Guadalupe | 1:3 | ||||
| 11. Jornada | 04.03.2021 | Guadalupe | - | LD Alajuelense | 1:3 | ||||
| 12. Jornada | 06.03.2021 | Limón FC | - | Guadalupe | 1:7 |  |
México