| 1. Jornada | 07.01.2022 | Puebla FC [Sub 20] | - | CF América [Sub 20] | 1:5 | ||||
| 2. Jornada | 15.01.2022 | UANL Tigres [Sub 20] | - | Puebla FC [Sub 20] | 4:1 |  |
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| 9. Jornada | 05.03.2022 | Cruz Azul [Sub 20] | - | Puebla FC [Sub 20] | 3:0 | ||||
| 16. Jornada | 22.04.2022 | Puebla FC [Sub 20] | - | Club Necaxa [Sub 20] | 1:3 |
México