| 3. Jornada | 09.07.2022 | Santos Laguna [] | - | CF Monterrey [] | 3:5 | ||||
| 8. Jornada | 13.08.2022 | Santos Laguna [] | - | UANL Tigres [] | 2:2 | ||||
| 13. Jornada | 17.09.2022 | Santos Laguna [] | - | Atlas Guadalajara [] | 2:0 |  |
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| 9. Jornada | 21.09.2022 | Club León [] | - | Santos Laguna [] | 4:1 | ||||
| 15. Jornada | 01.10.2022 | Mazatlán FC [] | - | Santos Laguna [] | 2:3 | ||||
| 16. Jornada | 08.10.2022 | Santos Laguna [] | - | Atlético San Luis [] | 4:0 | ||||
| 17. Jornada | 15.10.2022 | CF Monterrey [] | - | Santos Laguna [] | 1:1 | ||||
| 18. Jornada | 22.10.2022 | Santos Laguna [] | - | Club Tijuana [] | 1:0 |
México