| 1. Jornada | 03.08.2022 | Santos Laguna [Sub 18] | - | CF Monterrey [Sub 18] | 5:2 | ||||
| 9. Jornada | 18.08.2022 | Santos Laguna [Sub 18] | - | Club León [Sub 18] | 3:2 | ||||
| 5. Jornada | 14.09.2022 | CF América [Sub 18] | - | Santos Laguna [Sub 18] | 5:1 | ||||
| 15. Jornada | 18.09.2022 | Santos Laguna [Sub 18] | - | FC Juárez [Sub 18] | 4:2 | ||||
| 4. Jornada | 22.09.2022 | Deportivo Toluca [Sub 18] | - | Santos Laguna [Sub 18] | 4:0 |  |
México