| 2. Jornada | 13.09.2021 | APOEL Nikosia | - | Olympiacos Nikosia | 0:1 | ||||
| 4. Jornada | 27.09.2021 | APOEL Nikosia | - | PAEEK | 1:0 | ||||
| 5. Jornada | 03.10.2021 | Anorthosis Famagusta | - | APOEL Nikosia | 2:1 | ||||
| 7. Jornada | 24.10.2021 | Aris Limassol | - | APOEL Nikosia | 0:1 | ||||
| 8. Jornada | 30.10.2021 | Doxa Katokopias | - | APOEL Nikosia | 2:2 | ||||
| 9. Jornada | 06.11.2021 | APOEL Nikosia | - | AEL Limassol | 3:0 | ||||
| 12. Jornada | 05.12.2021 | APOEL Nikosia | - | Paphos FC | 1:1 | ||||
| 13. Jornada | 12.12.2021 | Olympiacos Nikosia | - | APOEL Nikosia | 1:1 |  |
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| 14. Jornada | 18.12.2021 | APOEL Nikosia | - | Apollon Limassol | 1:1 | |
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| 11. Jornada | 26.12.2021 | APOEL Nikosia | - | Omonia Nikosia | 4:2 | |
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| 17. Jornada | 15.01.2022 | Ethnikos Achna | - | APOEL Nikosia | 0:3 | ||||
| 18. Jornada | 23.01.2022 | APOEL Nikosia | - | Aris Limassol | 1:1 | ||||
| 19. Jornada | 30.01.2022 | APOEL Nikosia | - | Doxa Katokopias | 2:0 | ||||
| 21. Jornada | 14.02.2022 | APOEL Nikosia | - | AEK Larnaca | 1:0 | ||||
| 16. Jornada | 17.02.2022 | APOEL Nikosia | - | Anorthosis Famagusta | 0:2 | ||||
| 22. Jornada | 25.02.2022 | Omonia Nikosia | - | APOEL Nikosia | 2:4 |
R.D. Congo
Bélgica