| 1. Jornada | 17.09.2000 | Panachaiki GE | - | Skoda Xanthi | 1:1 | ||||
| 2. Jornada | 24.09.2000 | Iraklis Saloniki | - | Panachaiki GE | 2:0 |  |
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| 3. Jornada | 01.10.2000 | Panachaiki GE | - | Athinaikos | 3:1 | ||||
| 4. Jornada | 30.10.2000 | Ethnikos Asteras | - | Panachaiki GE | 3:1 | |
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| 5. Jornada | 06.11.2000 | Panachaiki GE | - | Ionikos Nikea | 2:3 | ||||
| 6. Jornada | 12.11.2000 | AEK Athen | - | Panachaiki GE | 2:1 | ||||
| 7. Jornada | 19.11.2000 | Olympiacos | - | Panachaiki GE | 3:0 | ||||
| 8. Jornada | 26.11.2000 | Panachaiki GE | - | PS Kalamata | 3:2 | ||||
| 9. Jornada | 03.12.2000 | PAS Giannina | - | Panachaiki GE | 1:1 | ||||
| 10. Jornada | 09.12.2000 | Panachaiki GE | - | Panionios GSS | 1:1 | |
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| 12. Jornada | 03.01.2001 | Panachaiki GE | - | OFI Heraklion | 2:1 | |
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| 13. Jornada | 07.01.2001 | Paniliakos Pyrgos | - | Panachaiki GE | 2:2 | |
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| 14. Jornada | 14.01.2001 | Panachaiki GE | - | Panathinaikos | 1:2 | |
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| 24. Jornada | 01.04.2001 | Panachaiki GE | - | PAS Giannina | 2:1 | ||||
| 26. Jornada | 20.04.2001 | Panachaiki GE | - | Aris Saloniki | 4:1 | ||||
| 29. Jornada | 20.05.2001 | Panathinaikos | - | Panachaiki GE | 4:0 |
Grecia