| 14. Jornada | 16.01.2022 | OFI Ierapetra | - | Asteras Vlachioti | 3:1 | ||||
| 6. Jornada | 19.01.2022 | Asteras Vlachioti | - | PS Kalamata | 0:0 | ||||
| 15. Jornada | 23.01.2022 | Asteras Vlachioti | - | GS Kallithea | 0:2 | ||||
| 17. Jornada | 06.02.2022 | Asteras Vlachioti | - | Irodotos | 1:3 | ||||
| 12. Jornada | 09.02.2022 | PAE Chania | - | Asteras Vlachioti | 3:1 | ||||
| 25. Jornada | 20.03.2022 | AE Karaiskakis | - | Asteras Vlachioti | 0:1 | ||||
| 26. Jornada | 26.03.2022 | Asteras Vlachioti | - | Ergotelis | 4:0 |  |
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| 28. Jornada | 03.04.2022 | Diagoras FC | - | Asteras Vlachioti | 2:0 | ||||
| 29. Jornada | 06.04.2022 | Asteras Vlachioti | - | PAE Chania | 0:0 | ||||
| 31. Jornada | 13.04.2022 | Asteras Vlachioti | - | OFI Ierapetra | 4:1 | ||||
| 32. Jornada | 17.04.2022 | GS Kallithea | - | Asteras Vlachioti | 5:1 |
Grecia