| 3. Jornada | 22.08.2021 | FC Differdange 03 | - | CS FOLA Esch | 1:1 | ||||
| 5. Jornada | 11.09.2021 | CS FOLA Esch | - | Progrès Niedercorn | 2:0 | ||||
| 4. Jornada | 15.09.2021 | CS FOLA Esch | - | Victoria Rosport | 4:4 | ||||
| 6. Jornada | 19.09.2021 | UNA Strassen | - | CS FOLA Esch | 2:2 |  |
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| 7. Jornada | 22.09.2021 | CS FOLA Esch | - | Swift Hesperange | 2:1 | ||||
| 8. Jornada | 26.09.2021 | FC Rodange 91 | - | CS FOLA Esch | 1:2 | ||||
| 9. Jornada | 17.10.2021 | CS FOLA Esch | - | RM Hamm Benfica | 2:1 |  |
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| 11. Jornada | 06.11.2021 | CS FOLA Esch | - | F91 Dudelange | 0:3 | ||||
| 12. Jornada | 21.11.2021 | Jeunesse Esch | - | CS FOLA Esch | 3:3 |  |
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| 13. Jornada | 28.11.2021 | CS FOLA Esch | - | US Hostert | 2:0 | ||||
| 14. Jornada | 04.12.2021 | RFCU Luxemburg | - | CS FOLA Esch | 0:1 | |
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| 15. Jornada | 11.12.2021 | CS FOLA Esch | - | Union Titus Pétange | 3:0 |
Portugal