| 3. Jornada | 25.07.2010 | Shakhtar Donetsk | - | Zorya Lugansk | 1:0 |  |
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| 4. Jornada | 30.07.2010 | Arsenal Kiev | - | Shakhtar Donetsk | 1:3 |  |
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| 5. Jornada | 07.08.2010 | Shakhtar Donetsk | - | PFK Sevastopol | 5:0 | ||||
| 6. Jornada | 15.08.2010 | Shakhtar Donetsk | - | Karpaty Lviv | 1:0 | ||||
| 7. Jornada | 21.08.2010 | Volyn Lutsk | - | Shakhtar Donetsk | 0:1 | ||||
| 8. Jornada | 29.08.2010 | Shakhtar Donetsk | - | FK Illichivets | 1:0 | ||||
| 13. Jornada | 15.10.2010 | Metalurh Donetsk | - | Shakhtar Donetsk | 0:2 | |
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| 14. Jornada | 23.10.2010 | Shakhtar Donetsk | - | Vorskla Poltava | 1:0 | ||||
| 15. Jornada | 30.10.2010 | Dnipro Dnipropetrovsk | - | Shakhtar Donetsk | 0:1 | ||||
| 16. Jornada | 06.11.2010 | FK Krivbas (old) | - | Shakhtar Donetsk | 0:2 | |
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| 17. Jornada | 13.11.2010 | Shakhtar Donetsk | - | Metalurg Zaporizhya | 2:1 | ||||
| 18. Jornada | 20.11.2010 | Zorya Lugansk | - | Shakhtar Donetsk | 1:3 | ||||
| 19. Jornada | 28.11.2010 | Shakhtar Donetsk | - | Arsenal Kiev | 4:0 | ||||
| 20. Jornada | 03.03.2011 | PFK Sevastopol | - | Shakhtar Donetsk | 0:1 | ||||
| 21. Jornada | 13.03.2011 | Karpaty Lviv | - | Shakhtar Donetsk | 1:0 | ||||
| 22. Jornada | 20.03.2011 | Shakhtar Donetsk | - | Volyn Lutsk | 4:0 |
Ucrania